Extracellular Matrix (ECM) Activates β-catenin Signaling in Uterine Fibroids
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چکیده
منابع مشابه
The Extracellular Matrix Contributes to Mechanotransduction in Uterine Fibroids
The role of the extracellular matrix (ECM) and mechanotransduction as an important signaling factor in the human uterus is just beginning to be appreciated. The ECM is not only the substance that surrounds cells, but ECM stiffness will either compress cells or stretch them resulting in signals converted into chemical changes within the cell, depending on the amount of collagen, cross-linking, a...
متن کاملExtracellular Matrix (ECM)
18.1 Context of the ECM ...................................................... 461 18.1.1 ECM – What’s in a Name? ............................................. 462 18.1.2 Old and New ECMs ........................................................ 462 18.1.3 Biophysical Considerations ............................................. 462 18.1.4 Jelly Bombs ................................................
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Pulmonary fibrosis (PF), characterized by the destruction of lung tissue architecture and the abnormal deposition of extracellular matrix (ECM) proteins, currently has no satisfactory treatment. In the present study, we investigated the hypothesis that XIST play a promotive role in bleomycin (BLM)-induced ECM and pulmonary fibrosis; XIST exerts its effect through miR-139 regulation. XIST expres...
متن کاملWnt–β-catenin signaling
will break the barrier, making the TJ a frequent contributor to a vast range of pathologies of blood vessels and epithelial organs. Since most of these insults have pleotropic cellular effects, it is difficult to envision therapies that could target specific TJ components or functions. In contrast, some assaults on the barrier are quite specific. For example, house dust mites excrete a fecal pr...
متن کاملUterine fibroids.
Copyright © 2013 Massachusetts Medical Society Uterine fibroids (leiomyomas) represent the most common tumor in women. These lesions disrupt the functions of the uterus and cause excessive uterine bleeding, anemia, defective implantation of an embryo, recurrent pregnancy loss, preterm labor, obstruction of labor, pelvic discomfort, and urinary incontinence and may mimic or mask malignant tumors...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2018
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-17-0339